Endocrinology and Metabolism

Original Article

Diabetes, Obesity and Metabolism
Association of Protein Z with Prediabetes and Type 2 Diabetes: Yun-Ui Bae, Ji Hong You, Nan Hee Cho, Leah Eunjung Kim, Hye Min Shim, Jae-Hyung Park, Ho Chan Cho; Endocrinol Metab. 2021;36(3):637-646. Published online June 2, 2021; DOI: https://doi.org/10.3803/EnM.2021.962

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Background
Type 2 diabetes mellitus (T2DM) is a progressive metabolic disease. Early detection of prediabetes is important to reduce the risk of T2DM. Some cytokines are known to be associated with T2DM. Therefore, we aimed to identify cytokines as novel biomarkers of glucose dysmetabolism.
Methods
The first stage of the study included 43 subjects (13 subjects with newly diagnosed T2DM, 13 with prediabetes, and 16 with normoglycemia) for cytokine microarray analysis. Blood samples of the subjects were assessed for 310 cytokines to identify potential indicators of prediabetes. The second stage included 142 subjects (36 subjects with T2DM, 35 with prediabetes, and 71 with normoglycemia) to validate the potential cytokines associated with prediabetes.
Results
We identified 41 cytokines that differed by 1.5-fold or more in at least one out of the three comparisons (normoglycemia vs. prediabetes, normoglycemia vs. T2DM, and prediabetes vs. T2DM) among 310 cytokines. Finally, we selected protein Z (PROZ) and validated this finding to determine its association with prediabetes. Plasma PROZ levels were found to be decreased in patients with prediabetes (1,490.32±367.19 pg/mL) and T2DM (1,583.34±465.43 pg/mL) compared to those in subjects with normoglycemia (1,864.07±450.83 pg/mL) (P<0.001). There were significantly negative correlations between PROZ and fasting plasma glucose (P=0.001) and hemoglobin A1c (P=0.010).
Conclusion
PROZ levels were associated with prediabetes and T2DM. We suggest that PROZ may be a promising biomarker for the early detection of prediabetes. Further large-scale studies are needed to evaluate the relationship and mechanism between PROZ and prediabetes and T2DM.

Citations

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Association of Protein Z with Prediabetes and Type 2 Diabetes (Endocrinol Metab 2021;36:637-46, Yun-Ui Bae et al.)
Ji Hong You, Yun-Ui Bae, Ho Chan Cho
Endocrinology and Metabolism.2021; 36(5): 1149. CrossRef
Association of Protein Z with Prediabetes and Type 2 Diabetes (Endocrinol Metab 2021;36:637-46, Yun-Ui Bae et al.)
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Review Article

Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation: Minsang Shin, Hye Suk Kang, Jae-Hyung Park, Jae-Hoon Bae, Dae-Kyu Song, Seung-Soon Im; Endocrinol Metab. 2017;32(1):11-17. Published online January 19, 2017; DOI: https://doi.org/10.3803/EnM.2017.32.1.11

4,951 View
67 Download
22 Web of Science
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Abstract PDF PubReader

Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.

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Eunwook Joo, Subeen Hong, Kyo Hoon Park, Hyeon Ji Kim, Min Jung Lee, Sue Shin
Archives of Gynecology and Obstetrics.2024;[Epub] CrossRef
The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications
Małgorzata Woronkowicz, Harry Roberts, Piotr Skopiński
Biology.2024; 13(3): 144. CrossRef
Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
Chiahsuan Chin, Ranjithkumar Ravichandran, Kristina Sanborn, Timothy Fleming, Stephen B. Wheatcroft, Mark T. Kearney, Sofya Tokman, Rajat Walia, Michael A. Smith, David J. Flint, Thalachallour Mohanakumar, Ross M. Bremner, Angara Sureshbabu
Cell Reports Medicine.2023; 4(3): 100945. CrossRef
Circulating IGF-1 and IGFBP-2 may be biomarkers for risk stratification in patients with acute coronary syndrome: A prospective cohort study
Wei Wang, Ying Sun, De-Gang Mo, Tai Li, Heng-Chen Yao
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American Journal of Cardiovascular Drugs.2023; 23(5): 497. CrossRef
Octopus death and dying
Z Yan Wang
Integrative And Comparative Biology.2023; 63(6): 1209. CrossRef
Efficient generation of functional pancreatic β cells from dental-derived stem cells via laminin-induced differentiation
Riham M. Aly, Hadeer A. Aglan, Ghada Nour Eldeen, Nadia S. Mahmoud, Eman H. Aboul-Ezz, Hanaa H. Ahmed
Journal of Genetic Engineering and Biotechnology.2022; 20(1): 85. CrossRef
Insulin-like growth factor signalling and its significance as a biomarker in fish and shellfish research
S. Chandhini, Bushra Trumboo, Seena Jose, Tincy Varghese, M. Rajesh, V. J. Rejish Kumar
Fish Physiology and Biochemistry.2021; 47(4): 1011. CrossRef
Nanomaterials for Chronic Kidney Disease Detection
Solmaz Maleki Dizaj, Aziz Eftekhari, Shakar Mammadova, Elham Ahmadian, Mohammadreza Ardalan, Soodabeh Davaran, Aygun Nasibova, Rovshan Khalilov, Mahbuba Valiyeva, Sevil Mehraliyeva, Ebrahim Mostafavi
Applied Sciences.2021; 11(20): 9656. CrossRef
Producción de las proteínas de unión al factor de crecimiento insulinoide durante el desarrollo de la fibrosis hepática por hepatitis C crónica
D. Rosique-Oramas, M. Martínez-Castillo, A. Raya, Z. Medina-Ávila, F. Aragón, J. Limón-Castillo, A. Hernández-Barragán, A. Santoyo, E. Montalvo-Javé, J.L. Pérez-Hernández, F. Higuera-de la Tijera, A. Torre, D. Kershenobich, G. Gutiérrez-Reyes
Revista de Gastroenterología de México.2020; 85(4): 390. CrossRef
Interacción cardiorrenal y evolución de la insuficiencia cardiaca. ¿Tiene un papel la proteína de unión del factor de crecimiento de tipo insulina 2?
Susana Ravassa, Javier Beaumont, Germán Cediel, Josep Lupón, Begoña López, Ramón Querejeta, Javier Díez, Antoni Bayés-Genís, Arantxa González
Revista Española de Cardiología.2020; 73(10): 835. CrossRef
Molecular identification of grass carp igfbp2 and the effect of glucose, insulin, and glucagon on igfbp2 mRNA expression
Guokun Yang, Wenli Zhao, Chaobin Qin, Liping Yang, Xiaolin Meng, Ronghua Lu, Xiao Yan, Xianglin Cao, Yanmin Zhang, Guoxing Nie
Fish Physiology and Biochemistry.2020; 46(4): 1469. CrossRef
Production of insulin-like growth factor-binding proteins during the development of hepatic fibrosis due to chronic hepatitis C
D. Rosique-Oramas, M. Martínez-Castillo, A. Raya, Z. Medina-Ávila, F. Aragón, J. Limón-Castillo, A. Hernández-Barragán, A. Santoyo, E. Montalvo-Javé, J.L. Pérez-Hernández, F. Higuera-de la Tijera, A. Torre, D. Kershenobich, G. Gutiérrez-Reyes
Revista de Gastroenterología de México (English Edition).2020; 85(4): 390. CrossRef
Cardiorenal interaction and heart failure outcomes. A role for insulin-like growth factor binding protein 2?
Susana Ravassa, Javier Beaumont, Germán Cediel, Josep Lupón, Begoña López, Ramón Querejeta, Javier Díez, Antoni Bayés-Genís, Arantxa González
Revista Española de Cardiología (English Edition).2020;[Epub] CrossRef
Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes
Emanuele Bosi, Lorella Marselli, Carmela De Luca, Mara Suleiman, Marta Tesi, Mark Ibberson, Decio L Eizirik, Miriam Cnop, Piero Marchetti
NAR Genomics and Bioinformatics.2020;[Epub] CrossRef
Transcriptional Analysis of FOXO1, C/EBP- and PPAR-2 Genes and Their association with Obesity-Related Insulin Resistance
Boughanem, Cabrera-Mulero, Millán-Gómez, Garrido-Sánchez, Cardona, Tinahones, Moreno-Santos, Macías-González
Genes.2019; 10(9): 706. CrossRef
Immune biomarkers in maternal plasma to identify histologic chorioamnionitis in women with preterm labor
Jeong Woo Park, Kyo Hoon Park, Song Yi Kook, Young Mi Jung, Yu Mi Kim
Archives of Gynecology and Obstetrics.2019; 299(3): 725. CrossRef
Insulin like growth factor binding protein 2 (IGFBP-2) for risk prediction in patients with severe aortic stenosis undergoing Transcatheter Aortic Valve Implantation (TAVI)
Johanna Maria Muessig, Michael Lichtenauer, Bernhard Wernly, Malte Kelm, Marcus Franz, Laura Bäz, Paul Christian Schulze, Victoria Racher, Georg Zimmermann, Hans-Reiner Figulla, Vera Paar, Uta C. Hoppe, Philippe Rouet, Alexander Lauten, Christian Jung
International Journal of Cardiology.2019; 277: 54. CrossRef
Molecular cloning and expression pattern of IGFBP-2a in black porgy (Acanthopagrus schlegelii) and evolutionary analysis of IGFBP-2s in the species of Perciformes
Xinyi Zhang, Zhiyong Zhang, Zhenpeng Yu, Jiayi Li, Shuyin Chen, Ruijian Sun, Chaofeng Jia, Fei Zhu, Qian Meng, Shixia Xu
Fish Physiology and Biochemistry.2019; 45(5): 1731. CrossRef
Current Insights into the Role of the Growth Hormone-Insulin-Like Growth Factor System in Short Children Born Small for Gestational Age
Judith S. Renes, Jaap van Doorn, Anita C.S. Hokken-Koelega
Hormone Research in Paediatrics.2019; 92(1): 15. CrossRef
Insulin-Like Growth Factor (IGF) System in Liver Diseases
Agnieszka Adamek, Aldona Kasprzak
International Journal of Molecular Sciences.2018; 19(5): 1308. CrossRef
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Hai-Lun Li, Zhuan Yan, Zun-Ping Ke, Xiao-Feng Tian, Li-Li Zhong, Yong-Tao Lin, Yong Xu, Dong-Hui Zheng
Oncotarget.2018; 9(93): 36551. CrossRef
Multiple optic gland signaling pathways implicated in octopus maternal behaviors and death
Z. Yan Wang, Clifton W. Ragsdale
Journal of Experimental Biology.2018;[Epub] CrossRef
Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes
Daniel Garcia de la Serrana, Daniel J. Macqueen
Frontiers in Endocrinology.2018;[Epub] CrossRef

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